反应详情

A solution of 2-[2-(2,5-dimethylphenoxymethyl)-phenyl]-2-hydroxy-N-methylacetamide (0.57 g, 1.9 mmol) and acetic anhydride (0.43 g, 4.2 mmol) in pyridine (3 ml) was stirred at room temperature for 8 hours, and then concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (n-hexane/ethyl acetate=1/1) to give the desired compound 2-acetoxy-2-[2-(2,5-dimethylphenoxymethyl)phenyl]-N-methylacetamide (0.53 g, 82%) as colorless crystals.

1. concentrationconcentrated under reduced pressure
2. customThe residue was purified by column chromatography on silica gel (n-hexane/ethyl acetate=1/1)