Ethanol → 2-Amino-4-methoxy-biphenyl

A Parr bottle charged with 4-methoxy-2-nitrobiphenyl (27.6 g, 120 mmol), Raney nickel (1.5 g), ethanol (100 mL), and H2O (100 mL) was rocked under hydrogen (60 psi) for 3 h. The suspension was filtered through Celite, the cake washed with ethanol (500 mL) and tetrahydrofuran (500 mL), and the filtrate concentrated in vacuo. The residual suspension was digested with CH2Cl2 (300 mL), washed with H2O (300 mL), and the organic portion extracted with 1 N HCl (4×200 mL). The combined extracts were made basic with 50% NaOH, extracted with CH2Cl2 (3×200 mL), and the organic extracts washed with brine (300 mL), dried (K2CO3), filtered, and concentrated in vacuo to give 24 g (100%) of the title compound which was used without further purification: 1H NMR (300 MHz, CDCl3) δ 3.78 (s, 3H), 3.90 (br s, 2H), 6.34 (d, J=2 Hz, 1H), 6.41 (dd, J=8, 2 Hz, 1H), 7.03 (d, J=8 Hz, 1H), 7.15-7.33 (m, 2H), 7.36-7.41 (m, 3H).

1. filtrationThe suspension was filtered through Celite
2. washthe cake washed with ethanol (500 mL) and tetrahydrofuran (500 mL)
3. concentrationthe filtrate concentrated in vacuo
4. washwashed with H2O (300 mL)
5. extractionthe organic portion extracted with 1 N HCl (4×200 mL)
6. extractionextracted with CH2Cl2 (3×200 mL)
7. washthe organic extracts washed with brine (300 mL)
8. dry with materialdried (K2CO3)
9. filtrationfiltered
10. concentrationconcentrated in vacuo

ORD record

ord-8ca26cf393ad4aa7b71f1a7fdbb284a2

Source dataset

uspto-grants-1999_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05948817