反应详情

Potassium permanganate (1.03 g, 6.55 mmol) was dissolved in water (25 mL). 5-Bromo-1,3-benzodioxole-4-carboxaldehyde (0.60 g, 2.62 mmol) was dissolved in acetone (25 mL) and slowly added to the permanganate solution and the reaction mixture was stirred at ambient temperature for 24 h at which time TLC analysis indicated the reaction complete. The reaction mixture was quenched with 5% sodium sulfite (100 mL). Concentrated HCl (10 mL) was added and the mixture turned a pale yellow color. The solution was extracted with ethyl acetate and the organic layers were dried with magnesium sulfate and concentrated by rotary evaporation to afford 0.34 g of product (1.39 mmol, 53% yield) as an off-white solid.

1. customThe reaction mixture was quenched with 5% sodium sulfite (100 mL)
2. additionConcentrated HCl (10 mL) was added
3. extractionThe solution was extracted with ethyl acetate
4. dry with materialthe organic layers were dried with magnesium sulfate
5. concentrationconcentrated by rotary evaporation