Thionyl Chloride → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

HRID 617423Notes

Reaction equation

HRID 617423 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([O-])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12][CH3:13])=[O:11].S(Cl)([Cl:16])=O>>[C:10]([C:2]1[CH:3]=[CH:4][C:5]([C:7]([Cl:16])=[O:8])=[CH:6][N:1]=1)([O:12][CH3:13])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 425561312,5-Pyridinedicarboxylic acid, 2-methyl ester

Product 1

HCID 151211775-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

Procedure

In step a, the carboxylic acid functionality of the appropriate 2,5-pyridinedicarboxylic acid, 2-methyl ester 10 (Nippon Kagaku Zasshi, 1967, 88, 563) is converted to its acid chloride using techniques and procedures well known and appreciated by one of ordinary skill in the art, such as thionyl chloride, to give the corresponding 6-carbomethoxynicotinoyl chloride 11.

Sources & evidence

ORD record
ord-12710f0f2f89454fb66fb185cd6524b5
Source dataset
uspto-grants-1999_09
Patent number
US05948886

Reaction notes

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