4-Fluorobenzylamine → HCID 18460274, compound

HRID 617480Notes

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[Cl:10][C:11]1[N:12]=[C:13](Cl)[C:14]2[C:19]3[CH2:20][CH2:21][CH2:22][CH2:23][C:18]=3[S:17][C:15]=2[N:16]=1>>[Cl:10][C:11]1[N:12]=[C:13]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=2)[C:14]2[C:19]3[CH2:20][CH2:21][CH2:22][CH2:23][C:18]=3[S:17][C:15]=2[N:16]=1

Participants

Reactant 2

HCID 673264-Fluorobenzylamine

HCID 2902342,4-Dichloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

Product 1

HCID 18460274HCID 18460274, compound

Procedure

Following the procedure of Example 1, the reaction of 4-fluorobenzylamine with 2,4-dichloro-5,6,7,8-tetrahydro-[1]-benzothieno-[2,3-d]-pyrimidine yields 2-chloro-5,6-,7,8-tetrahydro-4-(4-fluorobenzylamino)-[1]-benzothieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record: ord-9aca051b012342ebb3dd279cb76182ca
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948911

Reaction notes

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