HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 4-cyanobenzoate | HCID 70791 | — |
| Reactant | Ethyl 2-Amino-5-methylthiophene-3-carboxylate | HCID 4062885 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate | HCID 23289523 | 119.2% |
Reaction Steps
2-Amino-5-methyl-3-ethoxycarbonyl-thiophene (5 g) and 4-cyanobenzoic acid methylester (2.7 g) are dissolved in dioxane (40 ml). Gaseous HCl is conducted through the solution for 5 hours. The usual workup yields 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester (6 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948911 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-1cd8e040c27e420c96b6a60c232f5dd9 |
| Source note | uspto-grants-1999_09 |