3-Chloro-4-methoxybenzylamine → 4-[4-(3-Chloro-4-methoxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester

HRID 617521Notes

Reaction equation

HRID 617521 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH2:5][NH2:6].[CH3:12][O:13][C:14](=[O:32])[C:15]1[CH:20]=[CH:19][C:18]([C:21]2[N:22]=[C:23](Cl)[C:24]3[CH:29]=[C:28]([CH3:30])[S:27][C:25]=3[N:26]=2)=[CH:17][CH:16]=1>>[CH3:12][O:13][C:14](=[O:32])[C:15]1[CH:16]=[CH:17][C:18]([C:21]2[N:22]=[C:23]([NH:6][CH2:5][C:4]3[CH:7]=[CH:8][C:9]([O:10][CH3:11])=[C:2]([Cl:1])[CH:3]=3)[C:24]3[CH:29]=[C:28]([CH3:30])[S:27][C:25]=3[N:26]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 7380383-Chloro-4-methoxybenzylamineHCID 158405144-(4-Chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester

Product 1

HCID 232894294-[4-(3-Chloro-4-methoxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester

Procedure

The reaction of 3-chloro-4-methoxy-benzylamine with 4-(4-chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester yields 4-[4-(3-chloro-4-methoxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester.

Sources & evidence

ORD record
ord-53383d662466401d8b9a9aa1c11bb5cf
Source dataset
uspto-grants-1999_09
Patent number
US05948911

Reaction notes

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