4-Fluorobenzylamine → HCID 23289803, compound

HRID 617534Notes

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[CH3:10][O:11][C:12](=[O:30])[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:20]=[C:21](Cl)[C:22]3[C:27]([CH3:28])=[CH:26][S:25][C:23]=3[N:24]=2)=[CH:15][CH:14]=1>>[CH3:10][O:11][C:12](=[O:30])[C:13]1[CH:14]=[CH:15][C:16]([C:19]2[N:20]=[C:21]([NH:7][CH2:6][C:5]3[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=3)[C:22]3[C:27]([CH3:28])=[CH:26][S:25][C:23]=3[N:24]=2)=[CH:17][CH:18]=1

Participants

Reactant 2

HCID 673264-Fluorobenzylamine

HCID 23289806HCID 23289806, compound

Product 1

HCID 23289803HCID 23289803, compound

Procedure

The reaction procedure as above wherein 4-fluorobenzylamine is reacted with 4-(4-chloro-5-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester yields 4-[4-(4-fluorobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester.

Sources & evidence

ORD record: ord-1df4ac471f614afbb9889b82a8b90fac
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948911

Reaction notes

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