Methanol → Methyl 2-amino-4-(4-octylphenyl)butyrate hydrochloride

HRID 617579Notes

Reaction equation

HRID 617579 reaction equation
[ClH:1].[NH2:2][CH:3]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][CH:10]=1)[C:4]([OH:6])=[O:5].[CH3:23]O>S(Cl)(Cl)=O>[ClH:1].[NH2:2][CH:3]([CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:13][CH:14]=1)[C:4]([O:6][CH3:23])=[O:5]

Participants

4

Reactant 2

HCID 887MethanolHCID 701487132-Amino-4-(4-octylphenyl)butanoic acid hydrochloride

Product 1

HCID 22618877Methyl 2-amino-4-(4-octylphenyl)butyrate hydrochloride

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

To a solution of 2-Amino-4-(4-octylphenyl)butanoic acid hydrochloride (20 g) in methanol (500 ml), thionyl chloride (7.2 ml) was added under ice-cooling and the mixture was left standing overnight. The reaction mixture was concentrated under reduced pressure to give the subject compound (16 g).

Workup

  1. temperaturecooling
  2. waitthe mixture was left
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1a9a587c730b4906890f7d7bc63aa396
Source dataset
uspto-grants-1999_09
Patent number
US05948820

Reaction notes

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