3-Cyanopyridine → HCID 12218259, compound

Participants

Reaction Steps

To a mixture of chloroform (100 mL) and ethanol (200 mL) was added dropwise acetyl chloride (190 mL, 2.67 mol) under ice-cooling over 1 h. The resulting solution was stirred at oec for 30 min, whereafter a solution of 3-cyanopyridine (25.5 g, 245 mmol) in chloroform (300 mL) was added dropwise over 1.5 h. After stirring at room temperature for 17 h, precipitates were collected by filtration, washed with chloroform, and dried in vacuo to give 50.5 g (92%) of ethyl 3-pyridinecarboximidate dihydrochloride as colorless crystals.

Provenance & Evidence