1-Hydroxybenzotriazole → HCID 11028365, compound

Participants

Reaction Steps

2-[5-Benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidyl]-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide was synthesized in the same manner as in Example 1. That is, [5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]acetic acid (title compound in Reference Example 3, mixture with benzyl alcohol, 1.90 g, 4.48 mmol) was treated with 3-amino-1,1,1-trifluoro-4-phenyl-2-butanol (title compound in Reference Example 1, 1.00 g, 4.56 mmol), WSCI hydrochloride (1.03 g, 5.37 mmol) and HOBT (1.21 g, 8.95 mmol) in DMF (15 mL) to give 2.49 g (93%) of the target compound as colorless crystals.

Provenance & Evidence