1-Hydroxybenzotriazole → HCID 21851444, compound

Participants

Reaction Steps

2-(5-Benzyloxycarbonylamino-6-oxo-1,6-dihydro-1-pyrimidyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide was synthesized in the same manner as in Example 1. That is, (5-benzyloxycarbonylamino-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid (title compound in Reference Example 10, 1.20 g, 3.96 mmol) was treated with 3-amino-1,1,1-trifluoro-4-phenyl-2-butanol (title compound in Reference Example 1, 911 mg, 4.16 mmol), WSCI hydrochloride (912 mg, 4.76 mmol) and HOBT (1.07 g, 7.92 mmol) in DMF (15 mL) to give 1.85 g (93%) of the target compound as colorless crystals.

Provenance & Evidence