1-Hydroxybenzotriazole → HCID 21851390, compound

Participants

Reaction Steps

2-[5-Benzyloxycarbonylamino-6-oxo-2-(o-tolyl)-1,6-dihydro-1-pyrimidyl]-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide was synthesized in the same manner as in Example 1. That is, [5-benzyloxycarbonylamino-6-oxo-2-(o-tolyl)-1,6-dihydro-1-pyrimidinyl]acetic acid (title compound in Reference Example 12, 1.20 g, 3.05 mmol) was treated with 3-amino-1,1,1-trifluoro-4-phenyl-2-butanol (title compound in Reference Example 1, 709 mg, 3.23 mmol), WSCI hydrochloride (701 mg, 3.66 mmol) and HOBT (824 mg, 6.10 mmol) in DMF (15 mL) to give 1.66 g (92%) of the target compound as colorless crystals.

Provenance & Evidence