1-Hydroxybenzotriazole → HCID 21851391, compound

Participants

Reaction Steps

2-[5-Benzyloxycarbonylamino-2-(4-methoxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidyl]-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide was synthesized in the same manner as in Example 1. That is, [5-benzyloxycarbonylamino-2-(4-methoxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]acetic acid (title compound in Reference Example 14, 5.00 g, 12.2 mmol) was treated with 3-amino-1,1,1-trifluoro-4-phenyl-2-butanol (title compound in Reference Example 1, 2.94 g, 13.4 mmol), WSCI hydrochloride (2.81 g, 14.7 mmol) and HOBT (3.29 g, 24.3 mmol) in DMF (40 mL) to give 7.23 g (97%) of the target compound as colorless crystals.

Provenance & Evidence