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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 61771Generated: October 29, 2026

1-(2-Hydroxyethyl)piperazine → 8-[4-(2-Hydroxy-ethyl)-piperazin-1-carbonyl]-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

https://huagongshe.com/reaction/61771

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Hydroxyethyl)piperazineHCID 7677—
Reactant3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-carboxylic acidHCID 66834398—
Product8-[4-(2-Hydroxy-ethyl)-piperazin-1-carbonyl]-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrileHCID 66834692—

Reaction Steps

Under the same conditions as the method for synthesizing Compound B3-15, the title compound was prepared from Compound B2-28 and 2-piperazin-1-yl ethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440922B2
Source datasetuspto-grants-2016_09
ORD IDord-7a56c5125c864513b56b1a78eb56ee35
Source noteuspto-grants-2016_09