HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 17beta-Hydroxy-7alpha-methyl-11-methyleneestr-4-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 3-Methoxy-7alpha-methyl-11-methyleneestr-1,3,5(10)-trien-17-one | HCID 15549875 | — |
| Reactant | Lithium ammonia | HCID 57431548 | — |
| Product | 17beta-Hydroxy-7alpha-methyl-11-methyleneestr-4-en-3-one | HCID 57098977 | — |
Reaction Steps
3-Methoxy-7α-methyl-11-methyleneestr-1,3,5(10)-trien-17-one (A-11) was subjected to sodium borohydride reduction of the 17-ketone function, Birch reduction with lithium/NH3 (1), and acid hydrolysis and rearrangement to the title compound. Experimental details are as follows:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952319 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-4f0b46bb5b9d4267b216b7a5650bffd8 |
| Source note | uspto-grants-1999_09 |