Phenyl isocyanate → HCID 21846256, compound

Participants

Role	Name	HCID	Charge
Reactant	Phenyl isocyanate	HCID 7672	—
Reactant	4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine	HCID 196968	—
Solvent	Benzene	HCID 241	—
Product	HCID 21846256	HCID 21846256	12.3%

Reaction Steps

2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine (288.3 mg) was dissolved in benzene (50 mL) and phenyl isocyanate (119.1 mg) was added. The reaction mixture was heated to reflux for 48 hours, and the solvent was removed under vacuum. The residue was chromatographed on silica gel, eluting with hexane/ethyl acetate, to yield 1-[4-(4-fluoronaphth-1-yl)-6-isopropyl-pyrimidin-2-yl]-3-phenylurea (49.1 mg), m.p. 117-178° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05952331
Source dataset	uspto-grants-1999_09
ORD ID	ord-426c84050a2640c0b5b586d3338e1044
Source note	uspto-grants-1999_09