HCID 21849954, compound → HCID 15435323, compound

Participants

Reaction Steps

105.5 mg (0.29 mmol) of the compound of Example 8 was dissolved in acetic acid (1 ml). Then 36 μl of an 8 M borane/pyridine complex was added thereto under stirring at room temperature. The obtained mixture was stirred for 4.5 hours. After adding 30 μl of an 8 M borane/pyridine complex thereto, the obtained mixture was further stirred overnight and concentrated. Then it was extracted by adding thereto water, a saturated aqueous solution of sodium hydrogencarbonate and chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography. The product thus obtained was recrystallized from ethanol/diisopropyl ether to thereby give 22.6 mg of the title compound.

Provenance & Evidence