HCID 69843622, compound → HCID 69844447, compound

Participants

Reaction Steps

268 mg (0.641 mmol) of the free base of the compound of Example 27 was dissolved in acetic acid (10 ml) and 10% palladium-carbon was added thereto. Then catalytic reduction was effected at room temperature in a hydrogen atmosphere. After filtering off the palladium-carbon through celite, the filtrate was concentrated. Next, water and a saturated aqueous solution of sodium hydrogencarbonate were added thereto and the obtained mixture was stirred at room temperature. The precipitate was recovered by filtration, washed with water and suspended in methanol. After adding conc. hydrochloric acid thereto, the obtained mixture was stirred at room temperature. Thus it turned into a homogeneous solution and then a precipitate was formed. The precipitate was recovered by filtration to thereby give 179 mg of the title compound.

Provenance & Evidence