Hydrochloric Acid → HCID 21849908, compound

Participants

Reaction Steps

4 ml of triethylamine and 2 ml of acetic anhydride were successively added to a suspension of 141 mg (0.379 mmol) of the free base of the compound of Example 49 in dichloromethane (20 ml) under stirring at room temperature and stirring was continued for 16 hours. After concentrating, 30 ml of methanol was added to the residue. Next, the obtained mixture was made basic by adding an aqueous solution of sodium hydrogencarbonate thereto. The precipitate was recovered by filtration and washed with water. The solid matter thus obtained was suspended in ethanol and conc. hydrochloric acid was added thereto under stirring at room temperature. After further adding methanol and dichlromethane thereto, stirring was continued. After concentrating, ethanol was added thereto and the obtained mixture was heated under reflux and then brought back to room temperature. The precipitate was recovered by filtration to thereby give 148 mg of the title compound.

Provenance & Evidence