Sodium Hydroxide → HCID 21849432, compound

Participants

Reaction Steps

2-Acetamido-1,3-diacetoxy-2-(3-phenyl-2-propynyl)propane (430 mg) was dissolved in 8 ml of methanol and 8 ml of a 1 N aqueous sodium hydroxide solution was added thereto. The mixture was refluxed under heating for 2 hours. The solvent was distilled away and the residue was purified by silica gel column chromatography (methanol:chloroform=1:50-1:7) to give 230 mg of 2-amino-2-(3-phenyl-2-propynyl)-1,3-propanediol as a pale yellow, amorphous-like solid.

Provenance & Evidence