HCID 10854452, compound → HCID 10566696, compound

HRID 617889Notes

Reaction equation

HRID 617889 reaction equation
[CH2:1]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([N+:22]([O-])=O)([CH2:20][OH:21])[CH2:18][OH:19])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]>C(O)C.[C].[Pd]>[NH2:22][C:17]([C:14]1[CH:13]=[CH:12][C:11]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:16][CH:15]=1)([CH2:20][OH:21])[CH2:18][OH:19]

Participants

4

Reactant 1

HCID 10854452HCID 10854452, compound

Product 1

HCID 10566696HCID 10566696, compoundYield 5.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

2-(4-Decylphenyl)-2-nitro-1,3-propanediol (170 mg) was dissolved in ethanol (30 ml) and the mixture was subjected to catalytic reduction in the presence of 5% palladium carbon (40 mg) under hydrogen pressure of 20 atm. After stirring the mixture for 8 hours, the insoluble matters were filtered off and the filtrate was concentrated. The residue was purified by preparative thin layer chromatography (silica gel) to give 8.9 mg of the subject compound.

Workup

  1. filtrationthe insoluble matters were filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by preparative thin layer chromatography (silica gel)

Sources & evidence

ORD record
ord-a5a637303586440c8a5f8bc66ffe909e
Source dataset
uspto-grants-1999_09
Patent number
US05952316

Reaction notes

Loading…