HCID 11814484, compound → HCID 9845231, compound

Participants

Reaction Steps

1.9 g of benzyl (3S)-3-(1-dibenzylphosphonomethylcyclopentane-1-carbonylamino)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate (preparation see Example 1G) were dissolved in 100 ml of ethanol. 1.2 g of a 5% strength palladium catalyst on active carbon were added to the solution and it was hydrogenated for 3 hours at a hydrogen pressure of 5.5 bar. For workup, the catalyst was filtered out, the filtrate was evaporated in vacuo and the residue was dried. 0.9 g of the title compound was obtained as a foamy product, IR: 3400, 1720, 1630 cm-1 (KBr); [α]D20 =-140.8° (c=0.5 in methanol).

Provenance & Evidence