4-Methylmorpholine → HCID 57006984, compound

Participants

Reaction Steps

5.0 g of 1-benzylethylphosphonomethyl-1-cyclopentanecarboxylic acid (preparation see Example 3E)) were reacted with 5.15 g of tert-butyl (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate (preparation see Example 1E)), 4.1 ml of N-methylmorpholine, 2.0 g of hydroxybenzotriazole and 6.3 g of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride according to the method described in Example 1G). The resulting crude product was chromatographed on 200 g of silica gel (eluent: first n-hexane/ethyl acetate 1:1, then pure ester). 2.6 g of the title compound were obtained as a foamed resin, IR=3410, 3350, 1735, 1655 cm-1 ; [α]D20 =-118.1° (c=0.609 in methanol).

Provenance & Evidence