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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 617902Generated: October 25, 2026

1-Benzyloxycarbonylamino3-([1,8]naphthyridin-2-yl)-propane → 3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine

https://huagongshe.com/reaction/617902

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Benzyloxycarbonylamino3-([1,8]naphthyridin-2-yl)-propaneHCID 21850009—
ReactantHCID 178418361HCID 178418361—
CatalystHCID 178418390HCID 178418390—
SolventEthanolHCID 702—
Product3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amineHCID 9877599—

Reaction Steps

A mixture of 1-7 (0.40 g, 1.24 mmol) and 10% Pd/carbon (0.08 g) in EtOH (12 mL) was stirred under a balloon of hydrogen for 20 h. Filtration through a celite pad and then evaporative removal of the filtrate solvent gave 1-8 as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05952341
Source datasetuspto-grants-1999_09
ORD IDord-b76cde09736546e88cde543518f2299b
Source noteuspto-grants-1999_09