Boron tribromide → HCID 21850089, compound

HRID 617914Notes

Reaction equation

Cl.C[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:20]C)[CH:16]=3)[C:11]=2[C:22]2[CH:23]=[C:24]([O:28][CH2:29][CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]3)[CH:25]=[CH:26][CH:27]=2)=[CH:6][CH:5]=1.B(Br)(Br)Br>>[OH:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:20])[CH:16]=3)[C:11]=2[C:22]2[CH:23]=[C:24]([O:28][CH2:29][CH2:30][CH2:31][N:32]3[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]3)[CH:25]=[CH:26][CH:27]=2)=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 21850090HCID 21850090, compound

Product 1

HCID 21850089HCID 21850089, compoundYield 91.2%

Procedure

In a manner similar to that used in Example 3, 0.75 g (1.45 mmol) of 1-[3-[3-[2-(4-methoxyphenyl)-6-methoxynaphth-1-yl]phenyloxy]propyl]piperidine hydrochloride and 0.34 mL (3.62 mmol) of BBr3 were converted to 0.6 g of the title compound, isolated a tan amorphous powder.

Sources & evidence

ORD record: ord-4f127aa5bb2c4a71a540eba5cfee57a8
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05952350

Reaction notes

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