1,4-Dioxane--water (1/1) → HCID 178504544, compound

Participants

Reaction Steps

To predissolved SeO2 (2.95 g, 26.57 mmol) in dioxane/H2O mixture (100 mL:0.48 mL) at 60∞C, was added the ketone from Step 1 (14.4 g, 26 mmol) in solution in dioxane (70 mL). The reaction mixture was heated at 100∞C overnight. The reaction was cooled to room temperature and filtered through a pad of celite and washed with dioxane (20 mL). Evaporation to dryness yielded the title compound which was used as such in the next step (Crude weight 14 g).

Provenance & Evidence