Butyl isocyanate → 1-Butyl-3-[7-(3-butyl-ureido)-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-2-yl]-urea

HRID 617928ノート

反応式

HRID 617928 の反応式
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[CH:11]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[C:9]([NH2:20])=[N:8][C:6]=2[N:7]=1.[CH2:21]([N:25]=[C:26]=[O:27])[CH2:22][CH2:23][CH3:24]>>[CH2:21]([NH:25][C:26]([NH:1][C:2]1[N:3]=[CH:4][C:5]2[CH:11]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[C:9]([NH:20][C:26]([NH:25][CH2:21][CH2:22][CH2:23][CH3:24])=[O:27])=[N:8][C:6]=2[N:7]=1)=[O:27])[CH2:22][CH2:23][CH3:24]

参加物

3

反応物 2

HCID 8110Butyl isocyanateHCID 53281136-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

生成物 1

HCID 218500281-Butyl-3-[7-(3-butyl-ureido)-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-2-yl]-urea

実験手順

A mixture of 0.5 g 2,7-Diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine from Example 1 and 15 mL of n-butyl isocyanate is refluxed for 2 hours. The reaction mixture is allowed to cool to room temperature and the insoluble material filtered. The solid is recrystallized several times from ethanol to give the title compound; mp 200-202° C.

後処理

  1. temperatureis refluxed for 2 hours
  2. filtrationthe insoluble material filtered
  3. customThe solid is recrystallized several times from ethanol

出典と根拠

ORDレコード
ord-b2ea034bc0ca42c2b07b6c30c94f9162
出典データセット
uspto-grants-1999_09
特許番号
US05952342

反応ノート

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