tert-Butyl isocyanate → 1-[2-Amino-6-(2,3-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

HRID 617968Notes

Reaction equation

HRID 617968 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[C:19]([NH2:20])=[N:18][C:12]2[N:13]=[C:14]([NH2:17])[N:15]=[CH:16][C:11]=2[CH:10]=1.[C:21]([N:25]=[C:26]=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[NH2:17][C:14]1[N:15]=[CH:16][C:11]2[CH:10]=[C:9]([C:3]3[CH:4]=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=3[Cl:1])[C:19]([NH:20][C:26]([NH:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:27])=[N:18][C:12]=2[N:13]=1

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 218500486-(2,3-Dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Product 1

HCID 53291121-[2-Amino-6-(2,3-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

Procedure

Following the general procedure of Example 2, 0.502 g of 6-(2,3-dichlorophenyl)-pyrido[2,3-d]-pyrimidine-2,7-diamine from Example 83 was reacted with 0.206 mL of tert-butyl isocyanate. The product is purified by silica gel chromatography eluting with a gradient of CHCl3 :EtOAc (98:2) to CHCl3 :EtOAc (1:2) to afford the title compound; mp 356-358° C.

Workup

  1. customThe product is purified by silica gel chromatography
  2. washeluting with a gradient of CHCl3 :EtOAc (98:2) to CHCl3 :EtOAc (1:2)

Sources & evidence

ORD record
ord-bd41fc2f17084ff3ad76848a5f4fba04
Source dataset
uspto-grants-1999_09
Patent number
US05952342

Reaction notes

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