Ammonia → 1-[2-Amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-isopropyl-urea

Participants

Reaction Steps

The title compound was prepared from 0.5 g of 6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 1 and 0.172 mL of isopropyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to afford the pure product; mp 184-188° C., CIMS (1% ammonia in methane) m/z (relative intensity) 391 (MH+, 16), 393 (MH+ +2, 11), 306 (100).

Provenance & Evidence