tert-Butyl isocyanate → 1-[2-Amino-6-(3-methoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

HRID 617986Notes

Reaction equation

HRID 617986 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:19]([NH2:20])=[N:18][C:12]3[N:13]=[C:14]([NH2:17])[N:15]=[CH:16][C:11]=3[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[C:21]([N:25]=[C:26]=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[NH2:17][C:14]1[N:15]=[CH:16][C:11]2[CH:10]=[C:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[C:19]([NH:20][C:26]([NH:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:27])=[N:18][C:12]=2[N:13]=1

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 218500446-(3-Methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Product 1

HCID 53291281-[2-Amino-6-(3-methoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

Procedure

The title compound was prepared from 0.50 g of 6-(3-methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 102 and 0.23 mL tert-butyl isocyanate according to Example 2. The product was purified by medium pressure liquid chromatography eluting with a gradient of CHCl3 :EtOAc (2:1) to CHCl3 :EtOAc (1:1) to EtOAc; mp 275-280° C.; MS(CI).

Workup

  1. customThe product was purified by medium pressure liquid chromatography
  2. washeluting with a gradient of CHCl3 :EtOAc (2:1) to CHCl3 :EtOAc (1:1) to EtOAc

Sources & evidence

ORD record
ord-d7649446a0a54376b7d0b2b9d778b397
Source dataset
uspto-grants-1999_09
Patent number
US05952342

Reaction notes

Loading…