HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 170488-48-9
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Indole-3-Carboxaldehyde | HCID 10256 | — |
| Reactant | 3',4',5'-Trimethoxyacetophenone | HCID 14345 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 170488-48-9 | HCID 9927763 | 65.9% |
Reaction Steps
3',4',5'-Trimethoxyacetophenone (42.0 g) and indole-3-carboxaldehyde (29.0 g) were dissolved in ethanol (200 ml), and piperidine (17.0 g) was added thereto, followed by heating under reflux for 48 hours. The reaction solution was ice-cooled, and the precipitated crystals were collected by filtration to give Compound 1 (44.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952355 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-80521fa8bdf74a33bee9bce6142c3d8c |
| Source note | uspto-grants-1999_09 |