Ethyl chloroformate → HCID 15432608, compound

HRID 618093Notes

Reaction equation

HRID 618093 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1.[CH2:26]([O:28][C:29](Cl)=[O:30])[CH3:27]>N1C=CC=CC=1>[CH2:26]([O:28][C:29]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1)=[O:30])[CH3:27]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 9927763170488-48-9

Product 1

HCID 15432608HCID 15432608, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of Compound 1 (1.69 g) obtained in Example 1, ethoxycarbonyl chloride (2.5 ml) and pyridine (5 ml) was stirred at room temperature for 16 hours. The reaction solution was subjected to partitioning between chloroform and a 10% aqueous solution of citric acid. The organic layer was concentrated under reduced pressure, and the residue was recrystallized from 2-propanol to give Compound 7 (1.83 g).

Workup

  1. customto partitioning between chloroform
  2. concentrationThe organic layer was concentrated under reduced pressure
  3. customthe residue was recrystallized from 2-propanol

Sources & evidence

ORD record
ord-ba0a192054a648a5822c37a587bed9ff
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

Loading…