Methanesulfonyl chloride → HCID 15432610, compound

HRID 618095Notes

Reaction equation

HRID 618095 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[CH3:26][S:27]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)=[O:13])=[CH:2]1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 9927763170488-48-9

Product 1

HCID 15432610HCID 15432610, compoundYield 80.2%

Procedure

Substantially the same procedure as in Example 3 was repeated using Compound 1 (1.69 g) obtained in Example 1 and methanesulfonyl chloride (0.86 g) except that the reaction product was purified by silica gel column chromatography and that the obtained crude crystals were recrystallized from ethanol, to give Compound 9 (1.67 g).

Workup

  1. customwas purified by silica gel column chromatography
  2. customthat the obtained crude crystals
  3. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-0f975c5df368459f959b192a2ff91edf
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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