3',4',5'-Trimethoxyacetophenone → HCID 15432612, compound

HRID 618098Notes

Reaction equation

HRID 618098 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:15])[CH3:14])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH3:16][C:17]1[NH:18][C:19]2[C:24]([C:25]=1[CH:26]=O)=[CH:23][CH:22]=[CH:21][CH:20]=2>>[CH3:16][C:17]1[NH:18][C:19]2[C:24]([C:25]=1/[CH:26]=[CH:14]/[C:13]([C:5]1[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)=[O:15])=[CH:23][CH:22]=[CH:21][CH:20]=2

Participants

3

Reactant 2

HCID 143453',4',5'-TrimethoxyacetophenoneHCID 731663-Formyl-2-methylindole

Product 1

HCID 15432612HCID 15432612, compoundYield 60.7%

Procedure

Substantially the same procedure as in Example 1 was repeated using 3',4',5'-trimethoxyacetophenone (2.10 g) and 2-methylindole-3-carboxaldehyde (1.59 g) except that the obtained crude crystals were recrystallized from ethanol, to give Compound 12 (2.13 g).

Workup

  1. customobtained crude crystals
  2. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-daec4db48fc743a9b560d6a834e06294
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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