3',4',5'-Trimethoxyacetophenone → HCID 21850229, compound

HRID 618101Notes

Reaction equation

HRID 618101 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:15])[CH3:14])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[NH:24][C:25]3[C:30]([C:31]=2[CH:32]=O)=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[NH:24][C:25]3[C:30]([C:31]=2/[CH:32]=[CH:14]/[C:13]([C:5]2[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)=[O:15])=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 143453',4',5'-TrimethoxyacetophenoneHCID 27973362-(4-chlorophenyl)-1H-indole-3-carbaldehyde

Product 1

HCID 21850229HCID 21850229, compoundYield 169.9%

Procedure

Substantially the same procedure as in Example 12 was repeated using 3',4',5'-trimethoxyacetophenone (0.84 g) and 2-(4-chlorophenyl)indole-3-carboxaldehyde (2.56 g) to give Compound 14 (3.04 g).

Sources & evidence

ORD record
ord-7a8d64e2b4bd4df7a1de75cb5649c2a8
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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