3',4',5'-Trimethoxyacetophenone → HCID 21850214, compound

HRID 618106Notes

Reaction equation

HRID 618106 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:15])[CH3:14])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH3:16][O:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[C:21]2[CH:27]=O>>[CH3:16][O:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[C:21]2/[CH:27]=[CH:14]/[C:13]([C:5]1[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)=[O:15]

Participants

3

Reactant 2

HCID 143453',4',5'-TrimethoxyacetophenoneHCID 827585-Methoxyindole-3-carbaldehyde

Product 1

HCID 21850214HCID 21850214, compoundYield 52%

Procedure

Substantially the same procedure as in Example 1 was repeated using 3',4',5'-trimethoxyacetophenone (1.2 g) and 5-methoxyindole-3-carboxaldehyde (1 g) except that the obtained crude crystals were recrystallized from 2-propanol, to give Compound 25 (1.09 g).

Workup

  1. customobtained crude crystals
  2. customwere recrystallized from 2-propanol

Sources & evidence

ORD record
ord-1f12dfb7372842c794131a8be2237ac0
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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