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3',4',5'-Trimethoxyacetophenone → (E)-3-(6-Nitroindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3',4',5'-Trimethoxyacetophenone | HCID 14345 | — |
| 反応物 | 6-nitro-1H-indole-3-carbaldehyde | HCID 5210076 | — |
| 生成物 | (E)-3-(6-Nitroindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one | HCID 21850294 | 1.1% |
反応手順
Substantially the same procedure as in Example 21 was repeated using 3',4',5'-trimethoxyacetophenone (1.25 g) and 6-nitroindole-3-carboxaldehyde (1.13 g) except that the obtained product was further purified by preparative HPLC, that the eluting solution was cooled, and that the precipitated crystals were collected by filtration, to give Compound 34 (26 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05952355 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-b5d594092288441b837e6e6e11286f03 |
| 出典メモ | uspto-grants-1999_09 |