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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 618114Generated: October 25, 2026

3',4',5'-Trimethoxyacetophenone → (E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one

https://huagongshe.com/reaction/618114

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3',4',5'-TrimethoxyacetophenoneHCID 14345—
Reactant6-Methoxy-1H-indole-3-carboxaldehydeHCID 907214—
Product(E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-oneHCID 2185028332%

Reaction Steps

Substantially the same procedure as in Example 1 was repeated using 3',4',5'-trimethoxyacetophenone (659 mg) and 6-methoxyindole-3-carboxaldehyde (550 mg) except that the reaction solution was concentrated under reduced pressure, that the residue was purified by silica gel column chromatography, and that the obtained crude crystals were recrystallized from ethanol, to give Compound 39 (369 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05952355
Source datasetuspto-grants-1999_09
ORD IDord-f3c262c37ecd43e0955d3e99bad2ecf7
Source noteuspto-grants-1999_09