3,4,5-Trimethoxybenzaldehyde → 1-(3,4,5-Trimethoxyphenyl)pentan-1-one

HRID 618119Notes

Reaction equation

HRID 618119 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH:6]=[O:7].[CH2:15]([Li])[CH2:16][CH2:17][CH3:18]>>[CH3:14][O:13][C:9]1[CH:8]=[C:5]([C:6](=[O:7])[CH2:15][CH2:16][CH2:17][CH3:18])[CH:4]=[C:3]([O:2][CH3:1])[C:10]=1[O:11][CH3:12]

Participants

3

Reactant 2

HCID 68583,4,5-TrimethoxybenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 138919371-(3,4,5-Trimethoxyphenyl)pentan-1-one

Procedure

Substantially the same procedure as in Process 1 of Example 48 was repeated using 3,4,5-trimethoxybenzaldehyde (3.92 g) and butyl lithium (1.56M hexane solution, 15 ml) to give 1-(3,4,5-trimethoxyphenyl)-1-pentanone (2.84 g).

Sources & evidence

ORD record
ord-d640ff9c2f834094bdc3ce64e80ffca2
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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