3,4,5-Trimethoxybenzaldehyde → HCID 14792277, compound

HRID 618123Notes

Reaction equation

HRID 618123 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH:6]=[O:7].[CH2:15]([Mg]Br)[CH2:16][CH3:17]>>[CH3:14][O:13][C:9]1[CH:8]=[C:5]([C:6](=[O:7])[CH2:15][CH2:16][CH3:17])[CH:4]=[C:3]([O:2][CH3:1])[C:10]=1[O:11][CH3:12]

Participants

3

Reactant 2

HCID 68583,4,5-TrimethoxybenzaldehydeHCID 178455851HCID 178455851, compound

Product 1

HCID 14792277HCID 14792277, compound

Procedure

Substantially the same procedure as in Process 1 of Example 48 was repeated using 3,4,5-trimethoxybenzaldehyde (43.12 g) and propylmagnesium bromide (1.0 M tetrahydrofuran solution, 330 ml) to give 1-(3,4,5-trimethoxyphenyl)-1-butanone (17.43 g).

Sources & evidence

ORD record
ord-f41393d240304305993e21d80e19386a
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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