3,4,5-Trimethoxybenzaldehyde → HCID 15711809, compound

HRID 618124Notes

Reaction equation

HRID 618124 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH:6]=[O:7].[CH2:15]([Mg]Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:14][O:13][C:9]1[CH:8]=[C:5]([C:6]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:7])[CH:4]=[C:3]([O:2][CH3:1])[C:10]=1[O:11][CH3:12]

Participants

3

Reactant 2

HCID 68583,4,5-TrimethoxybenzaldehydeHCID 178419663HCID 178419663, compound

Product 1

HCID 15711809HCID 15711809, compound

Procedure

Substantially the same procedure as in Process 1 of Example 48 was repeated using 3,4,5-trimethoxybenzaldehyde (3.92 g) and benzylmagnesium bromide (2.0 M diethyl ether solution, 23 ml) to give 3,4,5-trimethoxydeoxybenzoin (3.51 g).

Sources & evidence

ORD record
ord-699df9f241534ab4841deb1015c0ac17
Source dataset
uspto-grants-1999_09
Patent number
US05952355

Reaction notes

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