HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ethanol ammonium hydroxide water
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 67601154 | HCID 67601154 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethanol ammonium hydroxide water | HCID 86596525 | — |
| Product | HCID 86754473 | HCID 86754473 | — |
Reaction Steps
Ester 4-5 (20 mg, 34 μmol) was dissolved in 350 μL EtOH, then 1 N NaOH (85 μL, 85 μmol) was added. After 2 h the reaction was diluted with EtOAc, washed with 10% KHSO4 and brine, dried (MgSO4), filtered and concentrated. The residue was dissolved in 1 mL CH2Cl2, treated with 1 mL TFA for 1 h, then concentrated and azeotroped with toluene. Flash chromatography (silica, 50:1:1, EtOH/H2O/NH4OH) provided 4-6 as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952306 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-15151bcfb982467eb47379859d4c787b |
| Source note | uspto-grants-1999_09 |