Sodium Hydroxide → 4-(Pyridin-4-yl)butanoyl-sarcosine

HRID 618149Notes

Reaction equation

HRID 618149 reaction equation
C([O:3][C:4](=[O:19])[CH2:5][N:6]([C:8](=[O:18])[CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[CH3:7])C.[OH-].[Na+]>CCO>[N:15]1[CH:14]=[CH:13][C:12]([CH2:11][CH2:10][CH2:9][C:8]([N:6]([CH2:5][C:4]([OH:19])=[O:3])[CH3:7])=[O:18])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 216997624-(Pyridin-4-yl)butanoyl-sarcosine ethyl ester

Product 1

HCID 206892654-(Pyridin-4-yl)butanoyl-sarcosine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ester 6-1 (324 mg, 1.22 mmol) was dissolved in 6 mL EtOH, then 1 N NaOH (2.4 mL, 2.4 mmol) was added. After stirring overnight the mixture was concentrated, rediluted with EtOAc, extracted into 10% KHSO4, then concentrated, providing acid 6-2, along with inorganic salts.

Workup

  1. concentrationwas concentrated
  2. additionrediluted with EtOAc
  3. extractionextracted into 10% KHSO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-d5a8552b1a9340628cadcb3f5461aec2
Source dataset
uspto-grants-1999_09
Patent number
US05952306

Reaction notes

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