反应详情

Cyclopropylamine (12.1 mL, 175 mmol) and TEA (42 mL, 385 mmol) were combined at 0° C. in 350 mL CH2Cl2, then ethyl bromoacetate (19.4 mL, 175 mmol) was added dropwise. The reaction was warmed to RT for 3 h, then diluted with additional CH2Cl2, washed with water, sat. NaHCO3, and brine, dried (Na2SO4), filtered and concentrated. Flash filtration (silica, 30% EtOAc/hexane) provided 7-2 as a light yellow oil.

1. washwashed with water, sat. NaHCO3, and brine
2. dry with materialdried (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated
5. filtrationFlash filtration (silica, 30% EtOAc/hexane)