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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 618163Generated: October 31, 2026

Glycine ethyl ester → 3-(4-t-Butoxycarbonyl-1-piperazinyl)benzoyl glycine

https://huagongshe.com/reaction/618163

Reaction equation

Participants

RoleNameHCIDCharge
ReactantGlycine ethyl esterHCID 12176—
Reactant3-(4-(Tert-butoxycarbonyl)piperazin-1-yl)benzoic acidHCID 44828726—
Product3-(4-t-Butoxycarbonyl-1-piperazinyl)benzoyl glycineHCID 54131744—

Reaction Steps

The acid 16-3 was coupled with glycine ethyl ester followed by hydrolysis of the resulting ester using previously described chemistry to yield 17-1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05952306
Source datasetuspto-grants-1999_09
ORD IDord-9c0aa2c641d34997a350f62b2f44d9e3
Source noteuspto-grants-1999_09