HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetate → N-[N'-[3-(1-Piperazinyl)benzoyl]glycyl]-3(S)-ethynyl-beta-alanine trifluoroacetic acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | 3-(4-t-Butoxycarbonyl-1-piperazinyl)benzoyl glycine | HCID 54131744 | — |
| Reactant | Ethyl (3s)-3-aminopent-4-ynoate hydrochloride | HCID 86751219 | — |
| Product | N-[N'-[3-(1-Piperazinyl)benzoyl]glycyl]-3(S)-ethynyl-beta-alanine trifluoroacetic acid salt | HCID 86754488 | — |
Reaction Steps
The acid 17-1 was coupled with 3(S)-ethynyl-β-alanine ethyl ester hydrochloride (Zablocki et al., J. Med. Chem., 1995, 38, 2378-2394) using standard peptide coupling conditions. The product was then fully deprotected using previously described methodology to give, after reverse phase chromatography, 17-4 as the trifluoroacetate salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952306 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-96fba85a7bfe49e9a10bcfac5281a527 |
| Source note | uspto-grants-1999_09 |