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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 618165Generated: October 30, 2026

Ethyl 4-(1,8-naphthyridin-2-yl)butanoate → Ethyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoate

https://huagongshe.com/reaction/618165

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-(1,8-naphthyridin-2-yl)butanoateHCID 10955797—
ReactantHCID 178418361HCID 178418361—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
ProductEthyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoateHCID 22594332—

Reaction Steps

A solution of 19-3 (2.3 g, 9.4 mmol) in 50 mL EtOAc was treated with 10% Pd/C (230 mg) and a hydrogen balloon. After 4 d the reaction filtered through celite, concentrated, and purified by flash chromatography (silica, 70% EtOAc/hexane), providing 19-4 as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05952306
Source datasetuspto-grants-1999_09
ORD IDord-0243bed824ca40b9818bd7d2a12f067d
Source noteuspto-grants-1999_09