HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(Pyridin-4-yl)piperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate | HCID 9899468 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(Pyridin-4-yl)piperidine-4-carboxylic acid | HCID 1268289 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of ester 21-1 (10 g, 42.7 mmol) in THF (50 mL) was treated with 1N LiOH (47 mL, 47.0 mmol) and H2O (50 mL). The resulting solution was concentrated and the aqueous residue cooled to 0° C., then adjusted to pH≈6 with 1N HCl and the resulting solid 21-2, collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952306 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-154c1f0538824074bb19588dd599f2b1 |
| Source note | uspto-grants-1999_09 |