HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 86754490, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 20689261 | HCID 20689261 | — |
| Product | HCID 86754490 | HCID 86754490 | — |
Reaction Steps
To a stirred solution of acid 23-6 (40 mg, 0.1256 mmol), amine 21-6 (33 mg, 0.1884 mmol), NMM (70 μl, 0.5024 mmol) and CH3CN (1 ml) was added BOP reagent (61 mg, 0.1382 mmol). After 20 h at ambient temperature, the solution was diluted with ethyl acetate and then washed with sat. NaHCO3, brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 40:1:1 CH2Cl2 /MeOH/AcOH) gave the ester 23-7 as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952306 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-c9b3642a6827453a927900f0327a7c6d |
| Source note | uspto-grants-1999_09 |